These models are the seminal Rip1-Tag2 model for pancreatic neuroendocrine neoplasia (Hanahan, 1985; Folkman et al., 1989), the K14-HPV16 model for squamous skin and cervical cancers (Arbeit et al., 1994; Coussens et al., 1996), and the MMTV-PyMT model for metastasizing breast cancer (Guy et al., 1992). The gene discussed is KRT14; the disease is cervical carcinoma.