APLP2 and familial pancreatic carcinoma: We observed high molecular mass APLP2, at the molecular mass previously shown to be modified by glycosaminoglycans (GAG) (20,34,35), in the majority of pancreatic cancer cell lines, as well as full-length APLP2 without GAG modification and 12–15 kDa C-terminal fragments generated from secretase cleavage (22,23) in all these cell lines.