Among the 5 samples with strong APLP2 staining, 4 were either moderate/poorly differentiated or poorly differentiated pancreatic adenocarcinoma, confirming our observation from the hTERT-HPNE cell lines that APLP2 expression may increase as pancreatic cancer cells diverge further from normal morphology. The gene discussed is APLP2; the disease is familial pancreatic carcinoma.