IL1B and adult-onset Still disease: IL-18-α member of the IL-1 family, which induces Th1 cytokine production-[44], has been shown to be higher in the serum synovial tissue and lymph nodes in patients with AOSD than in healthy individuals, serving as a marker of disease severity, possible response to corticosteroids and of AOSD-related hepatitis [29, 32, 33, 45].