BACE1 and Alzheimer disease: On the other hand, decreased activity in conjugated linoleic acid (CLA), acetylcholinesterase inhibitor galantamine (Gal), copper chaperone for superoxide dismutase (CCS), PPARγ coactivator-1α (PGC-1α), the trafficking molecule GGA3, as well as Fbx2-E3 ligase during AD can lead to increased BACE1 protein levels [177, 222–228].