Eosinophil aggregation in the gastrointestinal tract is a characteristic feature of various gastrointestinal conditions, including classic IgE-mediated food allergy [12], eosinophilic gastroenteritis [13], allergic colitis [14], eosinophilic esophagitis (EE) [15], inflammatory bowel disease (IBD) [16], and gastroesophageal reflux disease (GERD) [17]. Here, IGHE is linked to gastroesophageal reflux disease.