Despite the good results observed in all the reported studies, a recent report from the University of Nagasaki performed on 470 patients treated for HCC showed conflicting results, concluding that high AFP or DCP levels did not sufficiently reflect curative efficacy of treatment: hence, the authors affirmed AFP and DCP were poor predictors of prognosis in HCC patients [47]. This evidence concerns the gene ACE and hepatocellular carcinoma.