Indeed, in our study the mice bearing RGS5-expressing tumors that showed large areas of central necrosis were not treated with cytotoxic chemotherapy; however, if we had treated these mice with intravenous cisplatin or carboplatin, it is unclear whether these drugs could have reached the tumor parenchyma without a robust vasculature and what the effect on overall survival would have been. This evidence concerns the gene RGS5 and neoplasm.