Furthermore, proteins also involved in cell development, cancer and myocyte differentiation such as Cdc25, C/EBP homologous protein (CHOP), and kinases such as p38 activated/regulated protein kinase (PRAK) and mitogen- and stress-activated kinase (MSK1) have all be identified as p38 MAPK direct substrates (For review see [1, 28]). This evidence concerns the gene DDIT3 and cancer.