Interestingly, the frequency of the minor allele of rs7978987 that was significantly associated with higher VWF:Ag levels, was much lower in our type 1 VWD patients (MAF = 0.29) than reported by dbSNP (MAF = 0.38) and the CHARGE consortium (MAF = 0.35). The gene discussed is VWF; the disease is von Willebrand disease 1.