Human TNF-α, TNFR1-α, TGF-α, amphiregulin (AREG), and HB-EGF (ADAM17 substrates) were detected in the circulation of IGROV1-Luc tumour-bearing mice, with high concentrations in the ascites fluid and lower concentrations in the plasma (as shown in the vehicle control groups of the efficacy study, shown later). This evidence concerns the gene ADAM17 and neoplasm.