Thus, in UUO model, we have observed that treatment with an AT1 antagonist (losartan, 10 mg/kg/day), ameliorated disease progression, including inhibition of inflammatory cell infiltration and downregulation of MCP-1 gene overexpression (figure S1), and diminution of renal fibrosis (not shown) and TGF-β1 overproduction (figure S1), as previously described [38], [39]. Here, CCL2 is linked to renal fibrosis.