Notably, TPM3 hasbeen reported to control migration, invasion and anchorage-independent growthof HCC cells [37],and previously we have reported that GEP regulates growth, invasion and anchorage-independentgrowth of HCC cells [6].As the current study demonstrated TPM3 as the cytoplasmic interacting partnerof GEP, thus the two molecules may act together to control the invasion andanchorage-independent growth ability of the HCC cells. This evidence concerns the gene GRN and hepatocellular carcinoma.