LEF1 and neoplasm: These data support the observation that grade 1 tumors (defined as those in which 95% of the tumor is making well-defined glands and no more than 5% of the tumor is composed of solid components) express large amounts of Lef1, and grade 3 tumors (those in which 50% of the tumor is making well-defined glands and 50% is composed of solid components) express less Lef1 than other tumors, but more than inactive endometrium [33].