Top five canonical pathways from a total of 120 identified as significantly (p≤0.01) altered between cirrhosis aHCC vs. woHCC included PI3K/AKT signaling (p  = 3.46E-09), molecular mechanisms of cancer (p  = 1.16E-08), PTEN signaling (p = 1.04E-07), apoptosis signaling (p = 1.64E-07), and chronic myeloid leukemia signaling (p = 1.95E-06). This evidence concerns the gene PTEN and cancer.