To the best of our knowledge, however, this is the first study to investigate the association between in vitro BPDE-induced adducts and polymorphisms of the BER genes (XRCC1, PARP1, and APEX1), in which the APEX1 Asp148Glu polymorphism was shown to modulate levels of BPDE-induced DNA adducts, suggesting that APEX1 Asp148Glu may be one of the underlying mechanisms for the observed low host’s DRC involved in cancer susceptibility in the general population. The gene discussed is APEX1; the disease is cancer.