Li et al. reported that APEX1-148 Asp/Glu and Glu/Glu genotypes conferred a 1.67-fold (95%CI: 0.41–0.86) and 1.72-fold (95% CI: 0.38–0.88) decreased risk, respectively, of developing cutaneous melanoma [2]. The gene discussed is APEX1; the disease is cutaneous melanoma.