Inflammasome activation and IL-1β production are important inflammatory responses in a number of pathogens or conditions such as Muckle-Wells syndrome, Ebola virus, Marburg virus, gout, pseudogout, Crohn’s disease, asbestosis, silicosis, Systemic Inflammatory Response Syndrome (SIRS), etc. [24], [45], [46], [72], [73]. Here, IL1B is linked to Crohn disease.