Two GWASs for POAG in Caucasians have been reported, in which 3 genetic loci, caveolin 1 (CAV1) and caveolin 2 (CAV2) on 7q31[57], TMCO1 on1q24, and cyclin-dependent kinase inhibitor 2B antisense RNA (CDKN2BAS) on 9p21[58], were identified as susceptibility loci, while another GWAS of Japanese POAG patients provided only suggestive results [59]. Here, CAV2 is linked to open-angle glaucoma.