In Asian populations, we recently reported that DRB1*12:01 is a HLA-DRB1 susceptibility allele for ACPA-negative RA in Japanese populations and that DRB1*04:05, the most common SE allele in Japanese, and *14:03 showed moderate associations with ACPA-negative RA susceptibility [14]. Here, HLA-DRB1 is linked to rheumatoid arthritis.