We found that the similar associations were seen between the alleles/diplotypes and ACPA-negative RF-positive erosive RA and ACPA-negative RF-negative erosive RA (except for that between HLA-DRB1*12:01 and the ACPA-negative RF-negative subset), even though the number of patients was limited (Table S4). This evidence concerns the gene PRTN3 and rheumatoid arthritis.