Regarding HLA-DRB1 alleles that were previously shown to be associated with ACPA-negative RA, we found that all of the alleles, namely, HLA-DRB1*12:01, *04:05, *13:02, *14:03, and *15:02 showed association tendency with ACPA-negative RF-positive RA in the combined study (Table 1). Here, HLA-DRB1 is linked to rheumatoid arthritis.