While a previous report suggested that Hsp72 is not able to protect from the trypsin-induced pancreatitis, which is more severe than caerulein-induced injury [13], the extent of caerulein-induced pancreatitis in our hands seem to be comparable to the one reported by Bhagat and L-arginine induces a less severe pancreatic damage [12]. This evidence concerns the gene HSPA1A and pancreatitis.