CDKN2A and cervical squamous intraepithelial neoplasia: The specificity of p16 testing in screened women with normal or mild dyskaryosis predicting CIN 2+ disease has been shown to be similar to viral load testing at 68%; while the specificity of HPV 16, 18, 31, 33 and 45 mRNA testing for E6/E7 protein expression was the highest at 75% [32].