The SNPs in LEPR Gln223Arg, SPP1-66 T>G, IGF1R+3174 G>A, IGFBP3-202 A>C, FGF2+223 C>T and IL6-597 G>A, plus age and PSA remained independently associated with risk for overall, and for high-grade prostate cancer (Table 2). This evidence concerns the gene SPP1 and prostate cancer.