SPP1 and Familial prostate cancer: In the recessive effect models (referent: wild-type homozygotes and heterozygotes) a significantly increased risk was observed for IGF1R+3174 G>A (aOR = 1.3, 95%CI: 1.0–1.9 for overall prostate cancer), IGFBP3-202 A>C (aOR = 1.3, 95%CI: 1.0–1.8 and aOR = 1.3, 95%CI: 1.0–1.8, for overall and high-grade prostate cancer, respectively) and with SPP1-66 T>C (aOR = 1.8, 95%CI: 1.1–3.0, aOR = 1.9, 95%CI: 1.1–3.2 and aOR = 2.4, 95%CI: 1.2–4.8, in overall, high-grade and high-risk prostate cancer for metastasis, respectively).