We found functional variants in genes from leptin, osteopontin, insulin growth factor, fibroblast growth factor 2 and interleukin 6 pathways to be related with high-grade prostate cancer, while SNPs in the leptin, osteopontin and fibroblast growth factor 2 axis associate with high-metastasis risk prostate cancer. This evidence concerns the gene SPP1 and Familial prostate cancer.