TP53 and lung cancer: For example, Typhonium blumei extract induces cellular apoptosis via the mitochondrial/caspase pathway by upregulating the expression of proapoptotic proteins (e.g., Bax, Bad, and Bak), downregulating the expression of anti-apoptotic proteins (e.g., Bcl-2 and Bcl-xL), and activating caspase-9 and caspase-3 in lung cancer A549 cells [26], whereas Scutellaria baicalensis extract induces apoptosis by upregulating the expression of the proteins p53 and Bax in lung cancer A549 cells [25].