In order to ameliorate prognosis, with the support of granulocyte colony-stimulating factor (G-CSF), dose-dense chemotherapy CHOP14, administered every 14 days, with or without rituximab, was tested in elderly DLBCL at diagnosis; RICOVER-60 trial showed the superiority of 6 courses of R-CHOP14 compared to CHOP14, with 3-year event-free survival 66.5% versus 47.2% and 3-year overall survival 78.1% versus 67.7%, respectively [5]. Here, CSF3 is linked to diffuse large B-cell lymphoma.