Several molecular mechanisms have been suggested for their association, for example, insulin resistance leading to high cell proliferation by the activation of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway, elevated leptin/adiponectin linking to impaired anticancer immunity, and upregulated inflammation/tumor necrosis factor-alpha (TNF-α) leading to cancer cell survival; they produce a complex network with many-to-many correspondence [9, 10]. This evidence concerns the gene TNF and cancer.