EGLN2 and colitis: Additionally, chemical or genetic ablation of EGL-9 homolog PHD1 in intestinal epithelial cells diminished colitis caused by other toxins that disrupt the barrier, such as dextran sodium sulphate (DSS) and Clostridium difficile TcdbA and TcdB, suggesting that inhibition of PHD1 causes repression of the inflammatory response [23], [24].