In the full report by O’Connor et al.13, the grade 3 toxicities observed were lymphopenia (14 patients); thrombocytopenia (7 patients); hypokalemia, hyponatremia, infection without neutropenia, neuropathy, and prolonged pro-thrombin time (2 patients each); and alanine aminotransferase, alkaline phosphatase, hemoglobin, hyperkalemia, leukocytes, nausea, neutrophils, anorexia, constipation, and fatigue (1 patient each). This evidence concerns the gene GPT and Hyponatremia.