When we examined which genes that most frequently appeared in module B4 GeneSigDB gene signatures, we found several chemokines including CCL5 (RANTES), a key regulators of T-cell immune response highly expressed in breast cancer and reported to be associated with metastases and progression (Soria and Ben-Baruch, 2008; Zhang et al., 2009). This evidence concerns the gene CCL5 and breast carcinoma.