The chemokine CCL2 (formerly called MCP-1) is a critical mediator of neuroinflammation in a myriad of diseases states, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) [1], HIV-1 encephalitis [2], Guillain-Barré Syndrome [3], Alzheimer’s disease [4], ischemia [5], neurotrauma [6], epilepsy [7], neurogenic hypertension [8] and alcoholism [9]. Here, CCL2 is linked to alcohol dependence.