Although initially side-effects of anti-VEGF medications (endophthalmitis, rhegmatous retinal detachment, retinal tear, uveitis and vitreous hemorrhage) were supposed to be procedure- rather than medication-related, the large number of available data at this moment of the results of anti-VEGF therapies show that these treatment are accompanied of numerous unexpected side effects unrelated to the procedure used, including inflammation and fibrosis [24], development of RPE tears [30] and macular detachment [31]. The gene discussed is VEGFA; the disease is vitreous hemorrhage.