Receptor agonists, including recombinant forms of TRAIL and monoclonal antibodies against DR4 or DR5, are currently being evaluated in Phase II clinical trials in several cancer indications, in which at least four human or humanized monoclonal antibodies that target DR5 have been undergoing evaluation in clinical trials: Lexatumumab (HGS-ETR2), Apomab, Conatumumab (AMG 655), Tigatuzumab (CS1008). The gene discussed is TNFRSF10B; the disease is cancer.