Protein and mRNA expressions of Bax (mitochondrial) and caspase 3 (cleaved caspase 3 protein expression), two apoptotic biomarkers, were remarkably higher in obesity than in control and obese reduction, and the caspase 3 was notably higher in obese reduction than in control (all p<0.01), but Bax showed no difference between these two groups. The gene discussed is CASP3; the disease is obesity due to melanocortin 4 receptor deficiency.