Significant association of the double-positive status was observed with sex (P = 0.036), presence of vascular invasion (P < 0.001), VEGF expression (P = 0.018) and Ki-67 expression (P = 0.003), but not with age (P = 0.097), tumor differentiation grade (P = 0.150), SUVmax on FDG-PET (P = 0.168) (Table 4). This evidence concerns the gene MKI67 and neoplasm.