Cotrina and Thio et al. [18][28] also showed that HLA-DRB1*1301 and -DRB1*1302 alleles were associated with the clearance of HBV infection and protected people against chronic hepatitis B. Karan and Diepolder et al. [29][30] also observed that HLA-DR13 was present at a higher ratio in the group capable of creating spontaneous HBV antibody, suggesting that HLA-DR13 is associated with a self-course of HBV infection. Here, HLA-DRB1 is linked to chronic hepatitis B virus infection.