Although Pandiyan and colleagues suggested that Bim−/− T cells were resistant to Treg-mediated suppression in an inflammatory bowel disease (IBD) model (Pandiyan et al., 2007), we showed in two in vivo models that Bim−/− T cells could be effectively suppressed by Tregs and that Bim−/− T cells had a far greater propensity to convert into iTregsin vivo (Szymczak-Workman et al., 2011; Wang et al., 2012). Here, BCL2L11 is linked to inflammatory bowel disease.