PRRT2 and neoplasm: In the case of CTL-mediated tumor control, this can be explained by its role as a CTL survival factor (Barouch-Bentov et al., 2005), the impaired cytokine response observed in PKCθ deficient animals (Sun et al., 2000) and its implication in FasL expression (Villalba et al., 1999; Villunger et al., 1999; Pardo et al., 2003).