CHMP2B and frontotemporal dementia: Mutations in CHMP2B were first described in Danish and Belgian families but remain rare (Ghanim et al., 2010), yet accounting for less than 1% of Frontotemporal lobar degeneration linked to chromosome 3 (FTD-3; Isaacs et al., 2011; Gijselinck et al., 2012).