Staining of tissue from Alzheimer disease patients with CHMP2B showed an accumulation of the protein in vesicular structures resembling Granulo Vacuolar Degeneration (Yamazaki et al., 2010; Funk et al., 2011) suggestive of a defective autophagic and late endocytic pathways in AD and Frontotemporal lobar degeneration. The gene discussed is CHMP2B; the disease is frontotemporal dementia.