SGCB and cardiovascular disorder: Overall, these results do not support the hypothesis that activation of NO-insensitive sGC provides a greater beneficial effect on cardiovascular hemodynamics, including blood pressure, heart rate, vascular resistance, and end-organ damage, than does NO-sensitive sGC stimulation, but suggest that sGC activation might be advantageous over sGC stimulation for mitigating cardiac hypertrophy associated with cardiovascular disease.