In rodents, stress-induced release or exogenous administration of CRF and UCN I increased anxiety-like behaviors and stimulated colonic secretion, intestinal motility, and visceral sensitivity (Moreau et al., 1997; Slawecki et al., 1999; Saunders et al., 2002; Vetter et al., 2002; Million et al., 2003; Martinez et al., 2004; Tache et al., 2004, 2009). Here, CRH is linked to Anxiety.