However, more recently Sema3a has been found to bind to COS cells expressing Nrp2 (albeit 1.3 fold less than Nrp1 expressing COS cells), and a functional blocking antibody against Nrp2 removes the chemorepulsive effect of Sema3a on at least one human glioma cell line in vitro (Nasarre et al., 2009). Here, SEMA3A is linked to glioma.