TCF7L2 and type 2 diabetes mellitus: This is in line with a recent report from the prospective EPIC-Potsdam case-control study reporting that the association between whole-grain intake and protection against type 2 diabetes is dependent on TCF7L2 rs7903146 genotype; a high whole-grain intake was associated with protection among CC genotype carriers while individuals carrying one or two T alleles lacked such protection [12].