However, the risk of type 2 diabetes with the TCF7L2 T allele increased from 24% to 56% from the lowest (mean intake: 5.8 ± 0.8 g/4,184 kJ) to the highest (mean intake: 13.1 ± 2.2 g/4,184 kJ) quintile of fibre intake (pinteraction = 0.049). This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.