The bone turnover markers analysis revealed that the osteocalcin level was significantly reduced in Control group versus BD group (106.2 ± 8.4 ng/mL vs. 161.7 ± 16.8 ng/mL, p < 0.05) while no differences were observed between HF/HS group and both BD and Control groups (HF/HS = 119.7 ± 11.9 ng/mL; BD = 161.7 ± 16.8 ng/mL; Control =106.2 ± 8.4 ng/mL, NS). The gene discussed is BGLAP; the disease is hydrops fetalis.