The major mechanisms through which T2DM may influence AD include insulin resistance, impaired insulin receptor (IR), and insulin growth factor (IGF) signaling, glucose toxicity, advanced glycation endproducts (AGEs) and the receptor for advanced glycation endproducts (RAGEs), cerebrovascular injury, vascular inflammation, and others [5, 16–20]. Here, INSR is linked to type 2 diabetes mellitus.