Hence, in vitiligo, the lack of ZAG is expected to inhibit melanocyte proliferation, and if we consider the Langerhans cells (placed instead of melanocytes in vitiligo sites) as poorly differentiated melanocytes, this impairing in the process of maturation or differentiation of melanocytes can be attributed to the lack of ZAG. This evidence concerns the gene AZGP1 and vitiligo.