PAPPA and preeclampsia: In the study by F. Audibert et al. in 2010, it has been found that combination of mother's clinical characteristics and serum biomarkers (PIGF, Inhibin-A, and PAPP-A) in the first trimester was found in 75% of cases with early preeclampsia, but addition of uterine artery Doppler, PP13 and metalloproteinase 12 did not improve diagnosis of early preeclampsia [13].