Many virulence genes of H. pylori have been reported to determine clinical outcomes; among those of potential significance, especially with regards to gastric cancer, are the cytotoxin-associated gene A (cagA), the cytotoxin-associated gene T (cagT), the vacuolating cytotoxin gene (vacA), and the outer inflammatory protein gene (oipA). This evidence concerns the gene S100A8 and gastric cancer.