In a recent meta-analysis of 53 publications, the IL-1A C[−889]T and IL-1B C[3954]T polymorphisms, and the so-called composite genotype [9] maintained significant associations with chronic periodontitis especially in its severe form, indicating that these polymorphisms should continue to be considered as potential “genuine” genetic determinants of chronic periodontitis [10]. This evidence concerns the gene IL1B and chronic periodontitis.