One of the miRNA targets is miRNA-124a, which undergoes transcriptional inactivation by CpG island methylation in different human malignancies, in a similar way to that observed with tumor suppressor genes; in particular, a link was observed between the epigenetically mediated loss of function of miRNA-124a with the activation of the oncogenic factor cyclin D kinase 6 as well as the phosphorylation of the tumor suppressor gene RB1. The gene discussed is RB1; the disease is neoplasm.