In addition, GST pull-down assays of DU145 prostate cancer cells using individual GST-fused domains of BIN1 and PARP1 showed BIN1 bound to the automodification domain of PARP1 through the BIN-amphiphysin-Rvs-related (BAR-C) domain of BIN1. This evidence concerns the gene PARP1 and Familial prostate cancer.