An AR boost factor of 10 was intuitively expected to impact on tumour response in a biologically plausible manner, as there have been reported increases in tumour growth rate of up to 10 times (reducing the potential doubling time (Tpot) from approximately 10 to 20 days down to as low as 2 days [8, 65], approaching the stem cell division time. Here, AR is linked to neoplasm.