TAM recruitment in tumours is mediated by several cytokines, of which CCL2 seems to be the main player; other chemokines involved in monocyte recruitment are CCL5, CCL7, CXCL8, and CXCL12, as well as cytokines such as VEGF, PDGF, and the growth factor M-CSF [53]. This evidence concerns the gene VEGFA and neoplasm.