Incubating DCs with dead tumour cells (necrotic or apoptotic cells), as was shown in a pioneering article by the research group of Dr. Gregoire, DCs were exposed to a full array of antigenic peptides that rapidly gain access to both MHC Class I (cross-presentation) and MHC Class II pathways, therefore leading to a diversified immune response involving cytotoxic T lymphocytes (CTLs) as well as CD4+ T cells. This evidence concerns the gene CD4 and neoplasm.